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Gnupylot is a GUI for gnuplot (the widely used multi-OS plotting utility). It's written in Python using PyQt4 libraries. With Gnupylot you can save your plots (even the datasets). It's still in Alpha stage.
Real-time data visualization. Graphically view your data as it's being generated. Peakster is a very intuitive GUI written entirely in Python, which monitors data at regular intervals and uses gnuplot to render 2D, 3D and superimposed plots.